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Group publications (2018-present)

  1. Hodgson RE*, Rayment J, Huang WP, Sanchez Avila A, Ellis BCS, Lin YH, Soni N, Hautbergue GM, Shelkovnikova TA* (2024) C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology. iScience, 7(10):110937. 10.1016/j.isci.2024.110937
  2. Lang R^, Hodgson RE^, Shelkovnikova TA* (2024) TDP-43 in nuclear condensates: where, how, and why. Biochem Soc Trans. 52 (4): 1809–1825. 10.1042/BST20231447
  3. Huang WP^, Ellis B^, Hodgson R, Kumar V, Rayment J, Moll T, Shelkovnikova TA* (2024) Stress-induced TDP-43 nuclear condensation causes splicing loss-of-function and STMN2 depletion. Cell Rep., 43:114421. 10.1016/j.celrep.2024.114421 Spotlight in Trends in Neurosciences.
  4. Shelkovnikova TA*, Hautbergue G* (2024) RNP granules in ALS and neurodegeneration: from multifunctional membraneless organelles to therapeutic opportunities. Int. Rev. Neurobiol. 176:455-479. Book chapter.
  5. Mihaylov S, Castelli LM, Lin Y-H, Gul A, Soni N, Hastings C, Flynn HR, Paun O, Griffith L, Dickman MJ, Snijders A, Ule J, Goldstone R, Bandmann O, Shelkovnikova TA, Mortiboys H, Ultanir S, Hautbergue GM (2023) The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function. Nat Commun. 14(1):5496. 10.1038/s41467-023-41304-8
  6. Relton EL, Roth NJ, Yasa S, Kaleem A, Hermey G, Minnis CJ, Mole SE, Shelkovnikova T, Lefrancois S, McCormick PJ, Locker N. (2023) The Batten disease protein CLN3 is important for stress granules dynamics and translational activity. J Biol Chem. 299(5):104649.
  7. Bax BD, Sutormin D, McDonald N, Burley GA, and Shelkovnikova T (2022) Oligonucleotide-recognizing topoisomerase inhibitors (OTIs): precision gene editors for neurodegenerative diseases? Int J Mol Sci. 23(19):11541. (10.3390/ijms231911541)
  8. An H, Elvers KT, Gillespie JA, Jones K, Atack JR, Grubisha O, Shelkovnikova TA* (2022) A toolkit for the identification of NEAT1_2/paraspeckle modulators. Nucleic Acids Research, gkac771. https://doi.org/10.1093/nar/gkac771 
  9.  An H, Litscher G, Watanabe N, Wei W, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA* (2022) ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity. Neurobiol Dis. 162(105585). (10.1016/j.nbd.2021.105585)
  10. Matsukawa K, Kukharsky MK, Park SK, Park S, Watanabe N, Iwatsubo T, Hashimoto T, Liebman SW, Shelkovnikova TA* (2021) Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy. RNA Biol. 18(11): 1546–1554.  (10.1080/15476286.2020.1860580)
  11. Kukharsky MK, Ninkina NN, An H, Telezhkin V, Wei W, Rabesahala de Meritens C, Cooper-Knock J, Nakagawa S, Hirose T, Buchman VL, Shelkovnikova TA* (2020) Long non-coding RNA Neat1 mediates adaptive behavioural response to stress in mice. Transl Psychiatry. 10:171. 10.1038/s41398-020-0854-2 
  12. An H, Rabesahala de Meritens C, Buchman VL, Shelkovnikova TA* (2020) Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS. Mol Brain. 13:77. (10.1186/s13041-020-00618-0)
  13. An H, Shelkovnikova TA* (2019) Stress granules regulate paraspeckles: RNP granule continuum at work. Cell Stress. 3(12):385-387. Invited commentary. (10.15698/cst2019.12.207)
  14. An H, Tan J.-T., Shelkovnikova TA* (2019) Stress granules regulate stress-induced paraspeckle assembly. J Cell Biol. 218(12):4127-414. (10.1083/jcb.201904098)
  15. Shelkovnikova TA* et al. (2019) Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis. Cell Rep. 29(13):4496-4508.e4. (10.1016/j.celrep.2019.11.094)
  16. Park S, Park SK, Watanabe N, Hashimoto T, Iwatsubo T, Shelkovnikova TA, Liebman SW (2019) Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies. PLoS Genet. 15(8):e100830. (10.1371/journal.pgen.1008308)
  17. An H, Skelt L, Notaro A, Highley JR, Fox AH, La Bella V, Buchman VL*, Shelkovnikova TA* (2019) ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles. Acta Neuropathol Commun. 7(1):7. https://doi.org/10.1186/s40478-019-0658-x 
  18. An H, Williams NG, Shelkovnikova TA* (2018) NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found? Noncoding RNA Res. 3(4):243-252. Invited review https://doi.org/10.1016/j.ncrna.2018.11.003
TS - publications as PhD student/postdoc